Uremia/Azotemia

The term uremia, literally meaning urine in the blood, was first stated by Piorry to explain the clinical condition associated with kidney failure.

Uremia 

Definition

there is the accumulation of nitrogen-bearing waste products (such as urea) in the blood that are usually excreted in the urine. Uremia and azotemia are synonymous to each other..

Description 

Uremia is a clinical symptom characterized by high levels of urea in the blood and is associated with fluid imbalances, electrolytes, and hormones as well as metabolic abnormalities, which leads to coronary heart failure.

The Uremia usually progress with chronic kidney disease (CKD), especially the last stages of CKD, but can also occur with severe kidney damage (AKI) if rapid kidney function is lost.

Urea itself is a direct or indirect toxin for a variety of tissues. A number of toxic effects, such as parathyroid hormone (PTH), beta2 microglobulin, polyamines, enhanced glycosylation end products, and other intermediate molecules, are thought to be contributing to clinical syndrome.